前列腺素E分子网络对哺乳动物生殖的调控

磷脂酶A2、环氧合酶以及前列腺素E合成酶是前列腺素E合成途径中顺序起作用的重要酶类,其中前列腺素E合成酶有两种不同的亚型,分别介导不同的前列腺素E合成反应。前列腺素E可与其受体特异性结合,并通过旁分泌和自分泌两种形式调节细胞反应,参与多种生理过程。近来研究发现,前列腺素E受体不仅存于质膜,而在核膜上也大量存在。前列腺素E核受体介导的信号转导途径与膜受体介导的信号途径不同,对于基因转录的调控机制也不同。本文综述并探讨了上述分子所组成的网络系统在哺乳动物生殖,尤其是雌性生殖过程中所发挥的重要作用。

Regulation of prostaglandin E molecular network in mammalian reproduction

Prostaglandin E molecular network includes cyclooxygenase, phospholipase A2, prostaglandin E, prostaglandin E receptors, and prostaglandin E synthase. Recently, it was found that PGE2 receptors localized not only on the cell membrane but also on the envelope of nucleus. They are different in the signaling pathways and in regulation mechanism between nuclear receptors and membrane receptors. They compose a delicate network, which plays important roles in mammalian reproduction, especially in most processes of female reproduction.