Short-Term Regulation of the Proximal Tubule Na+,K+-ATPase: Increased/Decreased Na+,K+-ATPase Activity Mediated by Protein Kinase C Isoforms |
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Authors: | Carlos H Pedemonte Alejandro M Bertorello |
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Institution: | Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Texas 77204-5515, USA. pedemonte@uh.edu |
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Abstract: | In different species and tissues, a great variety of hormones modulate Na+,K+-ATPase activity in a short-term fashion. Such regulation involves the activation of distinct intracellular signaling networks that are often hormone- and tissue-specific. This minireview focuses on our own experimental observations obtained by studying the regulation of the rodent proximal tubule Na+,K+-ATPase. We discuss evidence that hormones responsible for regulating kidney proximal tubule sodium reabsorption may not affect the intrinsic catalytic activity of the Na+,K+-ATPase, but rather the number of active units within the plasma membrane due to shuttling Na+,K+-ATPase molecules between intracellular compartments and the plasma membrane. These processes are mediated by different isoforms of protein kinase C and depend largely on variations in intracellular sodium concentrations. |
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Keywords: | Na+ K+-ATPase Na pump sodium potassium-ATPase sodium pump sodium transport regulation protein kinase C PKC phosphoinositide-3 kinase polyproline motif serine phosphorylation |
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