Helicobacter pylori antigen-specific T-cell responses at gastric level in chronic gastritis,peptic ulcer,gastric cancer and low-grade mucosa-associated lymphoid tissue (MALT) lymphoma |
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| Authors: | D'Elios Mario M Amedei Amedeo Del Prete Gianfranco |
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| Institution: | Department of Internal Medicine, University of Florence, Viale Morgagni 85, 50134 Florence, Italy. delios@unifi.it |
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| Abstract: | Host T-cell response to Helicobacter pylori is important for the clinical outcome of the infection. A Th1-polarized response, preferentially against CagA, is associated with peptic ulcer, whereas mixed Th1 and Th0 responses are present in non-ulcer gastritis. A deregulated H. pylori-driven Th0 cell-dependent B-cell activation is found in low-grade B-cell lymphoma of mucosa-associated lymphoid tissue. |
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