The analysis of underivatized oligosaccharides by matrix-assisted laser desorption mass spectrometry. |
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Authors: | K K Mock M Davey J S Cottrell |
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Affiliation: | Finnigan MAT Ltd., Paradise, Hemel Hempstead, Herts, UK. |
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Abstract: | Matrix Assisted Laser Desorption Mass Spectrometry is shown to provide a rapid and sensitive technique for the analysis of underivatized oligosaccharides. Typical sample loading is 1 pmol and analysis time is around 5 minutes. Through the use of an internal standard, mass measurements are generally accurate to within 0.5 Da. The technique is particularly useful for the analysis of oligosaccharide mixtures released from glycoproteins. |
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