非小细胞肺癌患者血清淀粉样蛋白A水平与放射性肺炎的相关性研究

目的:评估非小细胞肺癌患者血清淀粉样蛋白A(SAA)水平与发生放射性肺炎(RP)的相关性。方法:选取我院确诊为非小细胞肺进行肺部病灶放射治疗的患者118例,评价是否发生放射性肺炎,并在放疗前及放疗剂量达到43 GY时分别抽取患者血清样本,应用酶联免疫法(ELISA)检测患者血清淀粉样蛋白A含量。结果:43例患者发生了放射性肺炎,发生放射性肺炎组患者的放疗前血清淀粉样蛋白A水平明显高于未发生放射性肺炎组,两组对比,差异有统计学意义(P0.05)。而在放疗剂量达到43Gy时,发生放射性肺炎组患者的血清淀粉样蛋白A水平与未发生放射性肺炎组患者相比,差别无统计学意义。结论:对于非小细胞肺癌患者,通过检测放疗前血清淀粉样蛋白A水平可以预测放射性肺炎的发生。

Study of Correlation Between SerumAmyloid A Level and RadiationPneumonitis in Patients with Non-Small Cell Lung Cancer

Objective:The purpose of this study is to evaluate the correlation between serum amyloid A level and radiationpneumonitis in patients with non-small cell lung cancer.Methods:118 cases of non-small cell lung cancer patients treated withradiotherapy in our hospital were collected and diagnosed with radiation pneumonitis. The serum amyloid A level of the patients weremeasured through using enzyme linked immunosorbent assay (ELISA) before radiation therapy and at the dose of 43 Gy.Results:43 outof 118 patients developed radiation pneumonitis, and the serum amyloid A level before radiation therapy in radiation pneumonitis groupwas significantly higher than that in non-radiation pneumonitis group(P<0.05). There was no significant difference between the Radiationpneumonitis group and non-radiation pneumonitis group in the serum amyloid A level at the dose of 43 Gy.Conclusion:Measuring theserumamyloid A level before radiation could predict the happening of radiation pneumonitis in patients with non-small cell lung cancer.