Cerebrovascular Endothelial Cell Culture: Metabolism and Synthesis of 5-Hydroxytryptamine |
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| Authors: | C Maruki M Spatz Y Ueki I Nagatsu † J Bembry |
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| Institution: | Laboratory of Neuropathology and Neuroanatomical Sciences, NINCDS, National Institutes of Health, Bethesda, Maryland, U.S.A.;Department of Anatomy, Fujita-Gakuen University School of Medicine, Toyoake, Aichi, Japan |
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| Abstract: | The presence of 5-hydroxytryptamine was investigated in cultured and propagated cerebrovascular endothelium using immunohistochemistry and high pressure liquid chromatography. These studies demonstrate that the endothelium has the ability to take up and metabolize 5-hydroxytryptamine as well as to synthesize this amine from its precursor L-tryptophan, thus providing evidence for extraneural synthesis of 5-hydroxytryptamine in the central nervous system. |
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| Keywords: | 5-Hydroxytryptamine Cerebrovascular endothelium |
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