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Association between 242C>T polymorphism of NADPH oxidase p22phox gene (CYBA) and longevity in Russian population |
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| Authors: | T V Zheykova M V Golubenko S V Buikin O Yu Botkina I V Tsimbaliuk V N Maksimov M I Voevoda V P Puzyrev |
| Institution: | 19789. Research Institute of Medical Genetics, Siberian Branch Russian Academy of Medical Sciences, Tomsk, 634050, Russia 29789. Siberian State Medical University, Tomsk, 634050, Russia 39789. Research Institute of Therapy, Siberian Branch Russian Academy of Medical Sciences, Novosibirsk, 630089, Russia |
| Abstract: | Life span depends on many factors, including the level of reactive oxygen species, like superoxide radical. Superoxide radical is produced from oxygen in the course of the oxidation of NADPH to NADP+. The process is catalyzed by NADPH oxidase. In this study, genotype and allele distributions of the C242T (rs4673) polymorphism in the CYBA gene, which encodes the α subunit of NADPH oxidase (p22phox), were examined in the sample of long livers and in the population sample of the city of Tomsk. Statistically significantly higher frequency of T allele among female long livers (34.625%), compared to the females from Russian population (26.32%) was demonstrated (χ2 = 5.226; p = 0.022; OR = 1.48). Thus, the T allele is associated with a high life expectancy in females from the Russian population. No such association was observed for males from the same population. |
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