Osteopontin,CCL5 and CXCL9 are independently associated with psoriasis,regardless of the presence of obesity |
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| Institution: | 1. Dermatology Department, Federal University of Bahia, Rua Padre Feijó s/n., Salvador, Bahia 40.110-150, Brazil;2. Immunology Department, Federal University of Bahia, Rua Padre Feijó s/n., Salvador, Bahia 40.110-150, Brazil;3. Centro de Pesquisa Gonçalo Moniz (Fiocruz), Salvador, Bahia, Brazil;1. Graduate School, Southern Medical University, Guangzhou 510515, China;2. Department of Cardiology, Guangzhou Liuhuaqiao Hospital, Guangzhou 510010, China;3. Department of Cardiology Hospital, Shanghai 200135, China;4. Department of Ultrasound, Guangzhou Liuhuaqiao Hospital, Guangzhou 510010, China;5. Department of Cardiology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China;6. Department of Cardiology, East Hospital, Tongji University, Shanghai 200120, China;1. Poisonous Plant Research Laboratory, Agricultural Research Service, United States Department of Agriculture, 1150 E. 1400 N., Logan, UT 84341, USA;2. Central de Diagnóstico Veterinário, Escola de Veterinária, Federal University of Pará (UFPA), Castanhal, Pará 68743-080, Brazil;3. Veterinary Hospital, Federal University of Campina Grande (UFCG), Patos, Paraíba 58700-000, Brazil;1. Clinical and Chemical Pathology Department, Faculty of Medicine, Cairo University, Giza, Egypt;2. Endemic Medicine Department, Faculty of Medicine, Cairo University, Giza, Egypt;3. Oncology Department, Dubai Hospital, Dubai, United Arab Emirates;1. Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan;2. Department of Internal Medicine and Clinical Immunology, Kyushu University Beppu Hospital, Beppu, Japan;3. Department of Medical Education, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan;4. Department of Arthritis and Immunology, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan;1. Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs, Beijing, China;2. Clinical Pharmacology Research Center, Peking Union Medical College Hospital, State Key Laboratory of Complex Severe and Rare Diseases, NMPA Key Laboratory for Clinical Research and Evaluation of Drug, Beijing Key Laboratory of Clinical PK & PD Investigation for Innovative Drugs, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 41 Damucang Hutong, Xicheng District, Beijing 100032, China;1. Department of Nutrition, Dietetics, and Hospitality Management, Auburn University, Auburn, AL, USA;2. Boshell Metabolic Diseases and Diabetes Program, Auburn University, Auburn, AL, USA |
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| Abstract: | Psoriasis is an autoimmune disease associated with the production of pro-inflammatory cytokines. The identification of these molecules in the pathogenesis of psoriasis facilitated the use of monoclonal antibodies to block their actions as a treatment for severe psoriasis. An increased inflammatory response has been documented in patients with obesity, a condition that is associated with the occurrence and severity of psoriasis. Osteopontin (OPN), TNF and CXCL9 levels are enhanced in patients with psoriasis, although OPN has been documented in the adipose tissue of obese patients without psoriasis. The prevalence of obesity is much higher in psoriasis patients compared with the general population. Thus, we aimed to evaluate the relationship between cytokine levels and psoriasis in the context of obesity. We compared OPN and CXCL9 plasma levels among 117 psoriasis patients and 27 healthy body mass index-matched subjects using ELISA. We also analyzed the TNF, CCL2 and CCL5 levels in a smaller subgroup of patients and matched controls. Median OPN, CCL5 and CXCL9 levels were significantly higher in psoriasis patients compared with the controls, independent of obesity. There was no difference between the median CCL2 levels in the psoriasis patients and the controls (P < 0.05), although the CCL2 levels were elevated in obese patients compared with non-obese psoriasis patients (P < 0.001). Facial involvement and the psoriasis area severity index (PASI) score were not associated (P < 0.05) with OPN levels or elevated levels of chemokines. There was no significant correlation between the OPN and CXCL9 levels or the OPN and TNF levels in psoriasis patients. This work confirms that OPN, CCL5 and CXCL9 plasma levels are higher in psoriasis patients and provides evidence that their higher levels are not a consequence of obesity. Furthermore, the results demonstrate that OPN production is independent of TNF-α and CXCL9. |
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| Keywords: | Severity Cytokines Biomarkers Comorbidities Obesity |
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