The influence of porosity on the hemocompatibility of polyhedral oligomeric silsesquioxane poly (caprolactone-urea) urethane |
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| Affiliation: | 1. Department of Surgery, Duke University Medical Center, Durham, NC, United States;2. University Program in Genetics and Genomics, Duke University, Durham, NC, United States;3. Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States;1. Department of Cardiology, University Heart Center, University Hospital Zurich, Zurich, Switzerland;2. University of Zürich, Zurich, Switzerland;3. Cantonal Hospital and Vascular Risk Foundation, Olten, Switzerland;4. Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland;1. Haematology Division, IMVS, SA Pathology, Adelaide, SA, Australia;2. School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, SA, Australia |
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| Abstract: | BackgroundThe physio-chemical properties of blood contacting biomaterials play an important role in determining their hemocompatibility. It is shown in literature that surface roughness and porosity have significant effect on hemocompatibility. In this study, we use a biocompatible, low thrombogenic nanocomposite polymer called POSS-PCU to test this hypothesis: would porosity compromise the hemocompatibility of POSS-PCU. We compared the hemocompatibility of POSS-PCU films of various pore sizes with PTFE, which is a commercially available material used in most blood contacting devices.MethodsSterilized POSS-PCU films with different size pores were prepared as samples and porous PTFE film were selected as control. And all samples were subjected to SEM for topograpgy, mechanical test for characterization and hemocompatibility tests to evaluate contact activation, platelet adhesion and activation, as well as whole blood clotting response to the samples.ResultsWCA significantly increased with the pore size of POSS-PCU film, whereas both tensile stress and strain decreased significantly as the sizes of pores increased. However, when compared to PTFE film with same size pores, POSS-PCU films showed both higher tensile stress and strain. Pore size had little impact over POSS-PCU's surface chemistry groups as tested by FTIR analysis. Contact activation and platelet adhesion essay also showed no significant difference between different POSS-PCU samples. However, in whole blood reactions, POSS-PCU with pores size around 2–5 μm showed higher BCI than plain films and those with pores size around 35–45 μm. POSS-PCU showed lower thrombogencity and higher hemocompatibility comparing with porous PTFE on the aspects of platelet activation, adhesion and whole blood reaction.Summary and conclusionsPOSS-PCU polymer films as a biomaterial in chronic blood contacting implants show significant lower thrombogencity and higher hemocompatibility than porous PTFE film. It is desirable as a coating or covering material in small diameter stents for treating cardiovascular diseases, cerebral vascular diseases and peripheral arterial diseases. |
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| Keywords: | Nanocomposite biomaterial Porosity Thrombogenicity Hemocompatibility Platelet adhesion Thrombelastograph |
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