Death-associated protein kinase 2: Regulator of apoptosis,autophagy and inflammation |
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| Affiliation: | 1. Department of Cell Biology, Myunggok Medical Research Institute, Konyang University College of Medicine, Daejeon 35365, South Korea;2. Department of Anatomy, Konyang University College of Medicine, Daejeon 35365, South Korea;3. Department of Stem Cell and Regenerative Biotechnology, Humanized Pig Research Center (SRC), Konkuk University, Seoul 05029, South Korea;1. Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan;2. Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan;3. Clinical Research Center in National Hospital Organization (NHO), Nagasaki Medical Center and Department of Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Omura, Japan;4. Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan;5. Division of Rheumatology, Allergy and Clinical Immunology, School of Medicine, University of California at Davis, Davis, CA, USA;1. Chemical Kinomics Research Center, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea;2. Division of Bio-Medical Science &Technology, KIST School, University of Science and Technology, Seoul, 02792, Republic of Korea;3. Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt;4. Medicinal Chemistry Laboratory, Department of Pharmacy, College of Pharmacy, Kyung Hee University, Seoul, 02447, Republic of Korea;5. Brain Science Institute, Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology (KIST), Seoul, 02791, Republic of Korea;6. Department of Life Science, Korea University, Seoul, 02841, Republic of Korea;7. Department of Life and Nanopharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul, Republic of Korea;8. BK21 PLUS Integrated Education and Research Center for Nature-inspired Drug Development Targeting Healthy Aging, Kyung Hee University, Seoul, Republic of Korea;9. Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology (KIST), Republic of Korea;1. Division of Tumor Immunology, Research Institute & Hospital, National Cancer Center, Goyang, Gyeonggi-do 410-769, Republic of Korea;2. Genome Analysis, Team Research Core Center, Research Institute & Hospital, National Cancer Center, Goyang, Republic of Korea;3. Center for Thyroid Cancer, Department of Otorhinolaryngology, Research Institute & Hospital, National Cancer Center, Goyang, Republic of Korea;4. Department of Biomedical Science, BK21-Plus Research Team for Bioactive Control Technology, College of Natural Sciences, Chosun University, 309 Pilmun-daero, Dong-gu, Gwangju 61452, Republic of Korea;5. Department of Biological Sciences, SRC Center for Immune Research on Non-lymphoid Organs, Sungkyunkwan University, Jangan-gu, Suwon, Republic of Korea;6. Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul, Republic of Korea;7. Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea;8. Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea;1. Department of Vascular Biology and Tumor Angiogenesis, European Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, Mannheim 68167, Germany;2. Metabolomics Core Technology Platform, Centre for Organismal Studies, Heidelberg University, Heidelberg 69120, Germany;3. Tissue Bank of the National Center for Tumor Diseases (NCT), Heidelberg 69120, Germany;4. CMCP - Center for Model System and Comparative Pathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg 69120, Germany;5. Electron Microscopy Lab, Institute of Pathology, University Hospital Heidelberg, Heidelberg 69120, Germany;6. Department of Internal Medicine I and Clinical Chemistry, Heidelberg University Hospital, Heidelberg 69120, Germany;7. German Center for Diabetes Research (DZD), München-Neuherberg 85764, Germany;8. Joint Heidelberg-IDC Translational Diabetes Program, Helmholtz-Zentrum, München, Heidelberg 69120, Germany |
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| Abstract: | Death-associated protein kinase 2 (DAPK2/DRP-1) belongs to a family of five related serine/threonine kinases that mediate a range of cellular processes, including membrane blebbing, apoptosis, and autophagy, and possess tumour suppressive functions. The three most conserved family members DAPK1/DAPK, DAPK2 and DAPK3/ZIPK share a high degree of homology in their catalytic domain, but differ significantly in their extra-catalytic structures and tissue-expression profiles. Hence, each orthologue binds to various unique interaction partners, localizes to different subcellular regions and controls some dissimilar cellular functions. In recent years, mechanistic studies have broadened our knowledge of the molecular mechanisms that activate DAPK2 and that execute DAPK2-mediated apoptosis, autophagy and inflammation. In this “molecules in focus” review on DAPK2, the structure, modes of regulation and various cellular functions of DAPK2 will be summarized and discussed. |
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| Keywords: | Apoptosis Autophagy Inflammation Death-associated protein kinase DAPK2/DRP-1 |
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