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Osteogenic differentiation of human MSCs: Specific occupancy of the mitochondrial DNA by NFATc1 transcription factor
Affiliation:1. Department of Biomedical and Specialty Surgical Sciences, University of Ferrara, Ferrara, Italy;2. Section of Pathology Oncology, Experimental Biology and Laboratory for Technologies of Advanced Therapies (LTTA), Department of Morphology, Surgery, Experimental Medicine, University of Ferrara, Ferrara, Italy;3. Laboratorio di Immunoreumatologia e Rigenerazione Tissutale, IOR, Bologna, Italy;4. CNR – National Research Council of Italy, Institute of Molecular Genetics, Bologna, Italy;5. Laboratory of Musculoskeletal Cell Biology, Istituto Ortopedico Rizzoli, Bologna, Italy;6. Department of Biomedical Sciences, University of Padova, Padova, Italy;1. Student, Dental Research Division, School of Dentistry, Paulista University, São Paulo, SP, Brazil;2. Professor, Dental Research Division, School of Dentistry, Paulista University, São Paulo, SP, Brazil;3. Professor, Dental Research Division, School of Dentistry, Paulista University, São Paulo, SP, Brazil;4. Professor, Dental Research Division, School of Dentistry, Paulista University, São Paulo, SP, Brazil;6. Professor, Dental Research Division, School of Dentistry, Paulista University, São Paulo, SP, Brazil;5. Professor, Dental Research Division, School of Dentistry, Paulista University, São Paulo, SP, Brazil;1. Experimental Surgery Group, Biomedical Research Institute of Murcia (IMIB-Arrixaca), University Clinical Hospital Virgen de la Arrixaca, 30120 Murcia, Spain;2. Experimental Pathology Unit, Biomedical Research Institute of Murcia (IMIB-Arrixaca), University Clinical Hospital Virgen de la Arrixaca, 30120 Murcia, Spain;3. Genomic Unit, Biomedical Research Institute of Murcia (IMIB-Arrixaca), University Clinical Hospital Virgen de la Arrixaca, 30120 Murcia, Spain;4. Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, 44121 Ferrara, Italy;1. State Key Laboratory of Cancer Biology and Experimental Teaching Center of Basic Medicine, Fourth Military Medical University, Xi''an, 710032, China;2. Department of Gastroenterology, Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China;3. Department of General Surgery, Tangdu Hospital, Fourth Military Medical University, Xi''an, 710032, China;4. Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, Xi''an, 710032, China
Abstract:
Keywords:Osteogenic differentiation  Mesenchymal stem cells  Mitochondria  NFATc1  Chromatin immunoprecipitation assay
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