Dendritic cells subsets mediated immune response during Plasmodium berghei ANKA and Plasmodium yoelii infection |
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| Affiliation: | 1. National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Key Laboratory of Parasite and Vector Biology, Ministry of Health, WHO Collaborating Center for Malaria, Schistosomiasis and Filariasis, Shanghai, People’s Republic of China;2. Hunan Institute of Schistosomiasis Control, Yueyang, People’s Republic of China;1. Clinical and Epidemiological Virology, Rega Institute for Medical Research, Department of Microbiology and Immunology, KU Leuven, Minderbroedersstraat 10, 3000 Leuven, Belgium;2. Debiopharm SA, Che. Messidor 5-7, P.O. Box 5911, 1002 Lausanne, Switzerland;3. Department of Hepatology, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium;4. Centro de Malária e Outras Doencas Tropicais and Unidade de Microbiologia, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Rua da Junqueira 100, 1349-008 Lisbon, Portugal;1. Yale Primary Care Residency Program and Waterbury Hospital, 64 Robbins Street, Waterbury, CT 06708, USA;2. Yale-New Haven Hospital, St. Raphael Campus, 1450 Chapel Street, New Haven, CT 06511, USA;3. St. Mary''s Hospital, 56 Franklin Street, Waterbury, CT 06706, USA;4. Griffin Hospital, 130 Division Street, Derby, CT 06418, USA;5. Western Connecticut Health Network, 24 Hospital Avenue, Danbury, CT 06810, USA |
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| Abstract: | The roles of dendritic cells (DCs) in mediating immunity against Plasmodium infection have been extensively investigated, but immune response during pathogenesis of malaria is still poorly understood. In the present study, we compared the splenic DCs phenotype and function during P. berghei ANKA (PbA) or P. yoelii (P. yoelii) infection in Swiss mice. We observed that PbA-infected mice developed more myeloid and mature DCs capable of secreting IL-12, while P. yoelii-infected mice had more plasmacytoid and immature DCs secreting higher levels of IL-10. Expression of FoxP3, IL-17, TGF-β and IL-6 were also different between these two infections. Thus, these results suggest that the phenotypic and functional subsets of splenic DCs are key factors for regulating immune responses to PbA and P. yoelii infections. |
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| Keywords: | Spleen Myeloid DC Plasmacytoid DC |
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