Supplemental vitamin D increases serum cytokines in those with initially low 25-hydroxyvitamin D: A randomized,double blind,placebo-controlled study |
| |
| Institution: | 1. Virginia Mason Medical Center, Seattle, WA, USA;2. Intermountain Health Care, Salt Lake City, UT, USA;1. Department of Exercise Physiology, Faculty of Sport Sciences, University of Guilan, Rasht, Iran;2. Orthopaedic Surgeon, Poorsina Hospital, Rasht, Iran;1. School of Mechanical and Electrical Engineering & Jiangsu Collaborative Innovation Center of Intelligent Mining Equipment, China University of Mining and Technology, Xuzhou 210008, China;2. Department of Mechanical Engineering, Kermanshah University of Technology, Kermanshah, Iran;3. Cihan Scientific Research Centre, Cihan University, Erbil, Kurdistan Region, Iraq;4. Physics Department, College of Education, Salahaddin University, Erbil, Kurdistan Region, Iraq;5. Department of Automotive and Marine Engineering Technology, College of Technological Studies, The Public Authority for Applied Education and Training, Kuwait;6. Laboratory of Magnetism and Magnetic Materials, Advanced Institute of Materials Science, Ton Duc Thang University, Ho Chi Minh City, Vietnam;7. Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City, Vietnam;1. Université Clermont Auvergne, INRA, UNH, CRNH Auvergne, F-63000 Clermont-Ferrand, France;2. IFR30, Inserm U563, CHU Purpan, Toulouse F-31024, France;3. Nutricia Research, Nutricia Advanced Medical Nutrition, Utrecht, the Netherlands;4. Université Clermont Auvergne, INRA, UNH, PFEM, CRNH Auvergne, F-63000 Clermont-Ferrand, France;5. CHU Clermont-Ferrand, Service Nutrition Clinique, F-63000 Clermont-Ferrand, France |
| |
| Abstract: | The purpose of this study was to determine if vitamin D status before supplementation influences the cytokine response after supplemental vitamin D. Forty-six reportedly healthy adults (mean(SD); age, 32(7) y; body mass index (BMI), 25.3(4.5) kg/m2; serum 25-hydroxyvitamin D (25(OH)D), 34.8(12.2) ng/mL) were randomly assigned (double blind) to one of three groups: (1) placebo (n = 15), or supplemental vitamin D (cholecalciferol) at (2) 4000 (n = 14) or (3) 8000 IU (n = 17). Supplements were taken daily for 35 days. Fasting blood samples were obtained before (Baseline, Bsl) and 35-days after (35-d) supplementation. Serum 25(OH)D, 1,25-dihydroxyvitamin D (1,25(OH)D), cytokines, and intact parathyroid hormone with calcium were measured in each blood sample. Supplemental vitamin D increased serum 25(OH)D (4000 IU, ≈29%; 8000 IU, ≈57%) and 1,25(OH)D (4000 IU, ≈12%; 8000 IU, ≈38%) without altering intact parathyroid hormone or calcium. The vitamin D metabolite increases in the supplemental vitamin D groups (n = 31) were dependent on initial levels as serum 25(OH)D (r = ?0.63, p < 0.05) and 1,25(OH)D (r = ?0.45, p < 0.05) at Bsl correlated with their increases after supplementation. Supplemental vitamin D increased interferon (IFN)-γ and interleukin (IL)-10 in subjects that were vitamin D insufficient (serum 25(OH)D < 29 ng/mL) compared to sufficient (serum 25(OH)D ? 30 ng/mL) at Bsl. We conclude that supplemental vitamin D increase a pro- and anti-inflammatory cytokine in those with initially low serum 25(OH)D. |
| |
| Keywords: | Serum 25-hydroxyvitamin D 1 25-Dihydroxyvitamin D Interferon-γ Interleukin-10 |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
