Beta cell contact and insulin release |
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Authors: | M Linzel A Ciccarelli R C Merrell |
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Institution: | Department of Surgery, University of Texas Medical School, Houston 77030. |
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Abstract: | Insulin secretion by intact islets, dispersed islet cells and dispersed cells allowed to reaggregate was compared in perifusion. Although single cells and aggregates showed basal insulin secretion and a prompt response to glucose challenge, basal secretion, peak insulin secretion and total insulin secretion during a 60 minute stimulation were profoundly less than those activities of intact islets. These results suggest that dispersed beta cells are responsive to glucose as a secretagogue, but the magnitude of the response is greatly diminished and not restored by simple cell contact. |
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