| 细胞穿膜肽介导蛋白/多肽类药物输送的研究进展 |
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| 引用本文： | 张娅洁,陈应之,杨志民,黄永焯.细胞穿膜肽介导蛋白/多肽类药物输送的研究进展[J].微生物学杂志,2015(4). |
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| 作者姓名： | 张娅洁 陈应之 杨志民 黄永焯 |
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| 作者单位： | 1. 中国科学院上海药物研究所，上海 201203；2. 天津医科大学药学院天津市临床药物关键技术重点实验室，天津 300070；3. 美国密西根大学
药学院，密西根州 安娜堡48109,1. 中国科学院上海药物研究所，上海 201203；2. 天津医科大学药学院天津市临床药物关键技术重点实验室，天津 300070；3. 美国密西根大学
药学院，密西根州 安娜堡48109,1. 中国科学院上海药物研究所，上海 201203；2. 天津医科大学药学院天津市临床药物关键技术重点实验室，天津 300070；3. 美国密西根大学
药学院，密西根州 安娜堡48109,1. 中国科学院上海药物研究所，上海 201203；2. 天津医科大学药学院天津市临床药物关键技术重点实验室，天津 300070；3. 美国密西根大学
药学院，密西根州 安娜堡48109 |
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| 基金项目： | 国家自然科学基金(No. 81373357, 81422048, 81172996,
81361140344) |
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| 摘 要： | 在当前药物研发中，蛋白/多肽类药物占据着重要地位。然而，此类药物大多需进入细胞内才能发挥作用，故细胞摄取率低的问
题成为制约其发展的关键因素。细胞穿膜肽是一类富含精氨酸的短肽，自身具有较强的生物膜穿透能力，可携带多种大分子甚至是纳米
粒入胞。因此，穿膜肽被广泛应用于药物输送，且基于穿膜肽介导药物胞内输送，成为解决蛋白/多肽类药物入胞问题的优选策略。主
要综述穿膜肽介导蛋白/多肽类药物输送用于不同疾病治疗的研究进展。
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| 关 键 词： | 细胞穿膜肽 蛋白 多肽 胞内输送 |
Recent Development in Cell-penetrating Peptides-mediated Protein/Peptide Drug Delivery |
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| ZHANG Yajie,CHEN Yingzhi,YANG Victor C.,and HUANG Yongzhuo.Recent Development in Cell-penetrating Peptides-mediated Protein/Peptide Drug Delivery[J].Journal of Microbiology,2015(4). |
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| Authors: | ZHANG Yajie CHEN Yingzhi YANG Victor C and HUANG Yongzhuo |
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| Institution: | 1. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; 2. Tianjin Key Laboratory on Technologies
Enabling Development of Clinical Therapeutics and Diagnosis, School of Pharmacy, Tianjin Medical University, Tianjin 300070, China; 3. College of
Pharmacy, University of Michigan, Ann Arbor 48109, USA,1. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; 2. Tianjin Key Laboratory on Technologies
Enabling Development of Clinical Therapeutics and Diagnosis, School of Pharmacy, Tianjin Medical University, Tianjin 300070, China; 3. College of
Pharmacy, University of Michigan, Ann Arbor 48109, USA,1. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; 2. Tianjin Key Laboratory on Technologies
Enabling Development of Clinical Therapeutics and Diagnosis, School of Pharmacy, Tianjin Medical University, Tianjin 300070, China; 3. College of
Pharmacy, University of Michigan, Ann Arbor 48109, USA and 1. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; 2. Tianjin Key Laboratory on Technologies
Enabling Development of Clinical Therapeutics and Diagnosis, School of Pharmacy, Tianjin Medical University, Tianjin 300070, China; 3. College of
Pharmacy, University of Michigan, Ann Arbor 48109, USA |
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| Abstract: | Protein/peptide drugs have received great attention and recognition, and taken a growing share in drug development. However,
intracellular delivery has become an essential issue for many protein/peptide drugs that need to enter the cells for achieving pharmacological actions.
Cell-penetrating peptides (CPPs) are rich in arginine, which enables them not only to penetrate cell membrane efficiently, but also to carry a variety
of macromolecules into cells. Therefore, CPPs have been widely applied in drug delivery, and especially, CPP-based technique is considered as the
promising solution to overcome the barriers against effective intracellular protein delivery. This article provided emphatically an overview on recent
development in CPP-mediated protein/peptide drug delivery for treatment of various diseases. |
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| Keywords: | cell-penetrating peptide protein peptide intracellular delivery |
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