| 小分子c-Met激酶抑制剂的研究进展 |
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| 引用本文： | 胡亚宁,胡诗合,袁浩亮,庄津,陈亚东,陆涛.小分子c-Met激酶抑制剂的研究进展[J].微生物学杂志,2015(3). |
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| 作者姓名： | 胡亚宁 胡诗合 袁浩亮 庄津 陈亚东 陆涛 |
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| 作者单位： | 1.中国药科大学有机化学教研室，江苏 南京 211198；2.中国药科大学无机化学教研室，江苏 南京211198,1.中国药科大学有机化学教研室，江苏 南京 211198；2.中国药科大学无机化学教研室，江苏 南京211198,1.中国药科大学有机化学教研室，江苏 南京 211198；2.中国药科大学无机化学教研室，江苏 南京211198,1.中国药科大学有机化学教研室，江苏 南京 211198；2.中国药科大学无机化学教研室，江苏 南京211198,1.中国药科大学有机化学教研室，江苏 南京 211198；2.中国药科大学无机化学教研室，江苏 南京211198,1.中国药科大学有机化学教研室，江苏 南京 211198；2.中国药科大学无机化学教研室，江苏 南京211198 |
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| 基金项目： | 国家自然科学基金( No．81473078) |
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| 摘 要： | 受体酪氨酸激酶c-Met即肝细胞生长因子HGF受体。HGF/c-Met信号通路在肿瘤形成、生长和转移过程中被频繁激活，因此, c-Met
已成为抗癌药物研究中一个重要靶标。重点介绍近年来基于c-Met通路的抗癌药物研究进展。
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| 关 键 词： | c-Met激酶 HGF/c-Met通路 c-Met抑制剂 肿瘤 |
Advances in Research on c-Met Kinase Inhibitors |
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| HU Yaning,HU Shihe,YUAN Haoliang,ZHUANG Jin,CHEN Yadong and LU Tao.Advances in Research on c-Met Kinase Inhibitors[J].Journal of Microbiology,2015(3). |
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| Authors: | HU Yaning HU Shihe YUAN Haoliang ZHUANG Jin CHEN Yadong and LU Tao |
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| Institution: | 1.Division of Organic Chemistry, China Pharmaceutical University, Nanjing 211198, China; 2.Division of Inorganic Chemistry, China
Pharmaceutical University, Nanjing 211198, China,1.Division of Organic Chemistry, China Pharmaceutical University, Nanjing 211198, China; 2.Division of Inorganic Chemistry, China
Pharmaceutical University, Nanjing 211198, China,1.Division of Organic Chemistry, China Pharmaceutical University, Nanjing 211198, China; 2.Division of Inorganic Chemistry, China
Pharmaceutical University, Nanjing 211198, China,1.Division of Organic Chemistry, China Pharmaceutical University, Nanjing 211198, China; 2.Division of Inorganic Chemistry, China
Pharmaceutical University, Nanjing 211198, China,1.Division of Organic Chemistry, China Pharmaceutical University, Nanjing 211198, China; 2.Division of Inorganic Chemistry, China
Pharmaceutical University, Nanjing 211198, China and 1.Division of Organic Chemistry, China Pharmaceutical University, Nanjing 211198, China; 2.Division of Inorganic Chemistry, China
Pharmaceutical University, Nanjing 211198, China |
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| Abstract: | c-Met kinase is the receptor for hepatocyte growth factor(HGF). HGF/c-Met is frequently activated during the development, growth and
metastasis of tumor. Therefore, c-Met becomes an important target in anti-cancer therapy. The advances in research on c-Met inhibitors recent years
have been reviewed in this paper. |
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| Keywords: | c-Met kinase HGF/c-Met signalling pathway c-Met inhibitor tumor |
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