| 酸性鞘磷脂酶/神经酰胺通路在疾病发生发展中
作用机制的研究进展 |
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| 引用本文： | 张阔军.酸性鞘磷脂酶/神经酰胺通路在疾病发生发展中
作用机制的研究进展[J].微生物学杂志,2015(11). |
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| 作者姓名： | 张阔军 |
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| 作者单位： | 1. 中国药科大学江苏省药物分子设计与成药性优化重点实验室，江苏 南京 210009；2. 中国药科大学高等职业技术学院，江苏 南京
210009；3. 中国药科大学生理教研室，江苏 南京 210009 |
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| 基金项目： | 国家自然科学基金面上项目（No. 81473231） |
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| 摘 要： | 酸性鞘磷脂酶/神经酰胺通路可介导细胞凋亡、炎症和自噬等多种细胞活动，与心脑血管疾病、代谢类疾病、肺部和肝部疾病以及
神经系统疾病等多种疾病的发生、发展密切相关。酸性鞘磷脂酶现已成为多种疾病的临床生物标记物和潜在的治疗靶点。综述酸性鞘磷脂
酶/神经酰胺通路在各种疾病中的生物学功能和作用机制最新研究进展，旨在为相关疾病的治疗提供新思路。
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| 关 键 词： | 酸性鞘磷脂酶 神经酰胺 细胞凋亡 疾病 |
Research Progress in Acidic Sphingomyelinase/
Ceramide Pathway: Its Role and Mechanism in
Development of Related Diseases |
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| ZHANG Kuojun.Research Progress in Acidic Sphingomyelinase/
Ceramide Pathway: Its Role and Mechanism in
Development of Related Diseases[J].Journal of Microbiology,2015(11). |
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| Authors: | ZHANG Kuojun |
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| Institution: | 1. Key Laboratory of Drug Design and Optimization of Jiangsu Provinve, China Pharmaceutical University, Nangjing 210009, China; 2. Altitude
Vocational School, China Pharmaceutical University, Nanjing 210009, China;3. Department of Physiology, China Pharmaceutical University, Nanjing
210009, China |
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| Abstract: | Acidic sphingomyelinase (ASMase)/ceramide (CE) pathway mediates various cellular processes including cell apoptosis, inflammation
and autophagy, and is closely associated with the development of many human diseases, including cardiovascular and cerebrovascular, metabolic,
pulmonary, hepatic and neurological disorders. ASMase has been regarded as a promising clinical biomarker and potential therapeutic target for many
diseases. The recent progress in investigations on the biological functions and mechanisms of ASMase/CE pathway in these diseases was reviewed, so
as to provide new ideas for the treatment of related diseases. |
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| Keywords: | acid sphingomyelinase ceramide apoptosis disease |
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