| 抗肿瘤靶点 PARP-1 及其抑制剂的研究进展 |
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| 引用本文： | 谢怡悦. 抗肿瘤靶点 PARP-1 及其抑制剂的研究进展[J]. 微生物学杂志, 2015, 0(10) |
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| 作者姓名： | 谢怡悦 |
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| 作者单位： | 中国药科大学药学院，江苏 南京 210009 |
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| 基金项目： | 国家自然科学基金 (No.81573348) |
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| 摘 要： | 聚二磷酸腺苷核糖聚合酶 -1（PARP-1）参与 DNA 损伤修复，是近年来肿瘤治疗领域的热门靶点。从 PARP-1 的结构和作用机制出发，综述 PARP-1 抑制剂的主要结构类型及优化思路，展望其应用前景和亟需解决的问题。
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| 关 键 词： | PARP-1；抑制剂；肿瘤 |
Progress in Research of Inhibitors Targeting PARP-1 forCancer Therapy |
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| XIE Yiyue. Progress in Research of Inhibitors Targeting PARP-1 forCancer Therapy[J]. Journal of Microbiology, 2015, 0(10) |
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| Authors: | XIE Yiyue |
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| Affiliation: | School of Pharmacy, China Pharmaceutical University, Nanjing 210009,China |
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| Abstract: | Poly(ADP-ribose) polymerase-1(PARP-1) plays an important role in repairing DNA damage and represents a currently important targetin cancer therapy. Based on the structure and mechanism of PARP-1, the major structure types of PARP-1 inhibitors and optimization strategies werereviewed, along with an outlook on their future applications and urgent problems to be solved. |
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| Keywords: | PARP-1 inhibitor cancer |
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