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Improved replicon cellular activity of non-nucleoside allosteric inhibitors of HCV NS5B polymerase: from benzimidazole to indole scaffolds |
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| Authors: | Beaulieu Pierre L Gillard James Bykowski Darren Brochu Christian Dansereau Nathalie Duceppe Jean-Simon Haché Bruno Jakalian Araz Lagacé Lisette LaPlante Steven McKercher Ginette Moreau Elaine Perreault Stéphane Stammers Timothy Thauvette Louise Warrington Jeff Kukolj George |
| Affiliation: | Boehringer Ingelheim, Canada, Ltd., Research and Development, 2100 Cunard Street, Laval, Québec, Canada H7S 2G5. pbeaulieu@lav.boehringer-ingelheim.com |
| Abstract: | Benzimidazole-based allosteric inhibitors of the hepatitis C virus (HCV) NS5B polymerase were diversified to a variety of topologically related scaffolds. Replacement of the polar benzimidazole core by lipophilic indoles led to inhibitors with improved potency in the cell-based subgenomic HCV replicon system. Transposing the indole scaffold into a previously described series of benzimidazole-tryptophan amides generated the most potent inhibitors of HCV RNA replication in cell culture reported to date in this series (EC(50) approximately 50 nM). |
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