| Abstract: | Authors applied the model system of intermittent hypoxic loading to study the development of early myocardial alterations. It was found that a primary role is played by the deficiency of high-energy phosphate synthesis and by the disturbance of energetic and transport processes. The change of Ca2+-control, activation of anaerobic glycolysis and intracellular acidosis were found to be instrumental in decreasing contractility, impairing membranes and finally in a diffuse destruction of myofilaments. |
