Effects of NO-synthase inhibitors on maturation mouse oocytes in cumulus-oocyte complexes |
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Authors: | T. Yu. Voznesenskaya T. V. Blashkiv |
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Affiliation: | (1) Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, ul. Bogomol’tsa 4, Kiev, 01024, Ukraine |
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Abstract: | We studied the effects of various NO-synthase inhibitors on meiotic maturation of mouse oocytes in vitro in cumulus-oocyte complexes isolated from follicles of varying sizes. Selective and nonselective inhibitors of NO-synthase isoforms suppressed meiotic maturation of oocytes to varying degrees, which was expressed in a decreased number of oocytes at metaphase II. The results obtained suggest that the role of inducible form of NO-synthase (iNOS) increases with the development of follicles and oocytes. |
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Keywords: | mouse oocyte meiotic maturation NO-synthase inhibitors |
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