Coronary hemodynamics and cardiac beating modulate atrial natriuretic factor release from isolated Langendorff-perfused rat hearts |
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| Authors: | M Naruse T Higashida K Naruse T Shibasaki H Demura T Inagami K Shizume |
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| Affiliation: | 1. Institute of Clinical Endocrinology, Department of Medicine, Tokyo Women''s Medical College, Tokyo 162, Japan;2. Department of Biochemistry and Hypertension Center, Vanderbilt University, Nashville, TN 37232, USA;1. School of Food and Biological Engineering, Shaanxi University of Science and Technology, Xi''an, Shaanxi, 710021, PR China;2. School of Life Science and Technology, Xian Jiaotong University, Xi''an, Shaanxi, 710049, PR China;3. Glyn O. Phillips Hydrocolloid Research Centre, School of Bioengineering and Food Science, Hubei University of Technology, Wuhan, 430068, China;4. Department of Food Science and Technology, Tokyo University of Marine Science and Technology, 4-5-7 Konan, Minato-ku, Tokyo, 108-8477, Japan;1. Department of Gastroenterology and Hepatology, the Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou 510006, Guangdong, China;2. Department of Hematology, Yantian District People''s Hospital, Shenzhen 518020, Guangdong, China;3. Department of Gastroenterology, Shenzhen People’s Hospital (the Second Clinical Medical College, Jinan University), Shenzhen 518020, Guangdong, China;4. Department of Medical Administration, Huizhou Institute of Occupational Diseases Control and Prevention, Huizhou 516000, Guangdong, China;5. Department of Emergency, Shenzhen People''s Hospital (the Second Clinical Medical College, Jinan University; the First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, Guangdong, China;6. Department of Child and Adolescent Psychiatry, Shenzhen Kangning Hospital, Shenzhen Mental Health Center, Shenzhen 518020, Guangdong, China;7. Department of Gastroenterology, Shenzhen People''s Hospital (the Second Clinical Medical College, Jinan University; the First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, Guangdong, China;8. Shenzhen Clinical Research Centre for Geriatrics, Shenzhen People''s Hospital, Shenzhen 518020, Guangdong, China |
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| Abstract: | ![]()
The role of coronary hemodynamics and cardiac beating on atrial natriuretic factor (ANF) release was studied in the isolated Langendorff-perfused rat heart. ANF release was measured by radioimmunoassay. When the coronary flow rate was changed, ANF release decreased or increased in a flow-dependent manner. When the perfusion pressure was changed, ANF release also increased or decreased, respectively, with concomitant changes in coronary flow rate. Furthermore, perfusion with 50 mM potassium chloride showed immediate cardiac arrest and a decrease of ANF release to an undetectable level with a significant decrease in coronary flow. However, low but readily detectable amounts of ANF were released when coronary flow rate was maintained. These results may suggest that coronary hemodynamics and cardiac beating could be factors modulating ANF secretion from the atrium. |
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