A transcribed polymorphism and sub-localisation of MDM2 |
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| Authors: | Jim Heighway Erika L D Mitchell David Jones Gavin R M White Mauro F Santibáñez Koref |
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| Institution: | (1) CRC Department of Cancer Genetics, Paterson Institute for Cancer Research, Christie CRC Research Centre, M20 9BX Manchester, UK |
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| Abstract: | An NlaIV polymorphism in the 5 untranslated region of the MDM2 gene is described. MDM2 was sublocalised by fluorescence in situ hybridisation with a yeast artifical chromosome probe to 12q14.3–12q15. We demonstrate the use of the polymorphism to assess allelic imbalance in breast tumours. |
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