A gene locus affecting tolerance to BGG in mice. |
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Authors: | Miodrag L. Lukic Henry H. Wortis Sidney Leskowitz |
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Affiliation: | Department of Pathology, Tufts University School of Medicine, Boston, Massachusetts 02111 U.S.A. |
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Abstract: | A genetic analysis was made of the ease of tolerance induction to bovine γ-globulin (BGG) in DBA/2, BALB/c, F1 and backcross generation mice. Like parental DBA/2 mice, the F1 generation of BALB/c × DBA/2 becomes tolerant when treated with 2 mg BGG. A backcross of this F1 to DBA/2 parents produced mice that all became tolerant to this dose of BGG. A backcross of F1 mice to BALB/c parents produced 50% offspring tolerized by the same dose of BGG and 50% resistant to tolerance induction.The data suggest a single autosomal locus affecting tolerance induction. Data presented elsewhere suggest that the locus affects macrophage function. We propose that this locus be called tolerance (symbol Tol-l) and the two alleles be (Tol-la (DBA/2 type) and Tol-lb (BALB/c type) with Tol-la being dominant. |
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Keywords: | Author to whom reprint requests should be directed. |
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