| 脑室注射高低渗NaCl溶液对血浆肾素活性及肾交感神经活动的影响 |
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| 引用本文： | 张延玲,柴象枢. 脑室注射高低渗NaCl溶液对血浆肾素活性及肾交感神经活动的影响[J]. 生理学报, 1987, 39(5): 530-534 |
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| 作者姓名： | 张延玲 柴象枢 |
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| 作者单位： | 山东省医学科学院基础医学所生理室 济南(张延玲)，山东省医学科学院基础医学所生理室 济南(柴象枢) |
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| 摘 要： | 第三脑室注射高渗NaCl溶液可引起肾交感神经活动(RSNA)减弱和血浆肾素活性(PRA)降低,低渗NaCl的作用则相反,引起KSNA及PRA升高。PRA和RSNA变化呈一定的正相关,切除肾神经后高、低渗NaCl对PRA的影响减弱或消失,表明脑室内Na~ 浓度改变后主要经肾交感神经的传出通路影响肾素释放。
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| 关 键 词： | 脑室注射 肾交感神经 血浆肾素 |
EFFECTS OF BRAIN VENTRICULAR INJECTION OF HYPERTONIC/HYPOTONIC NaCl SOLUTIONS ON PLASMA RENIN ACTIVITY AND RENAL SYMPATHETIC NERVE ACTIVITY |
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| ZHANG YAN-LING,CHAI XIANG-SHU. EFFECTS OF BRAIN VENTRICULAR INJECTION OF HYPERTONIC/HYPOTONIC NaCl SOLUTIONS ON PLASMA RENIN ACTIVITY AND RENAL SYMPATHETIC NERVE ACTIVITY[J]. Acta Physiologica Sinica, 1987, 39(5): 530-534 |
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| Authors: | ZHANG YAN-LING CHAI XIANG-SHU |
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| Affiliation: | ZHANG YAN-LING,CHAI XIANG-SHU Department of Physiology,Shandong Academy of Medical Science,Jinan |
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| Abstract: | Injection of hypertonic NaCl solution into 3rd ventricle of the brain markedlydecreases the renal sympathetic nerve activity (RSNA) and plasma renin activity(PRA). The effects of hypotonic NaCl solution were opposite to those due tohypertonic NaCl. In either cases of NaCl injection the PRA and RSNA changeswere positively correlative. The effects of hypertonic or hypotonic NaCl injectionon PRA were eliminated after a renal denervation. Therefore it appears thatrenin release due to the change of sodium ion concentration in cerebrospinal fluidis mediated by efferent renal sympathetic nerves. |
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| Keywords: | intraventricular injection renal sympathetic nervs plasma renin |
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