Synthesis and biological evaluation of novel bisphosphonates with dual activities on bone in vitro |
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| Authors: | Xie Yuli Ding Huasheng Qian Lihui Yan Xueming Yang Chunhao Xie Yuyuan |
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| Affiliation: | Department of Medicine, Columbia University, NY 10032, USA. |
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| Abstract: | In an effort to generate novel anti-osteoporosis agents, new bisphosphonates with various benzoyl groups on side chains have been synthesized and evaluated for activities on both bone resorption and bone formation in vitro. Several candidates showed distinct dual activities: promoting bone formation and inhibiting bone resorption. |
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