ABO exon and intron analysis in individuals with the AweakB phenotype reveals a novel O1v-A2 hybrid allele that causes four missense mutations in the A transferase |
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Authors: | Bahram Hosseini-Maaf ?sa Hellberg Maria J Rodrigues M Alan Chester Martin L Olsson |
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Affiliation: | (1) Dept. of Transfusion Medicine, Institute of Laboratory Medicine, Lund University & Blood Centre, University Hospital, SE-221 85 Lund, Sweden;(2) Centro Regional de Sangue de Lisboa/IPS, Lisboa, Portugal |
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Abstract: | Background Since the cloning in 1990 of cDNA corresponding to mRNA transcribed at the blood-group ABO locus, polymorphisms due to ethnic and/or phenotypic variations have been reported. Some subgroups have been explained at the molecular level, but unresolved samples are frequently encountered in the reference laboratory. |
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