Enhancement of the sliding velocity of actin filaments in the presence of ATP analogue: AMP-PNP |
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| Authors: | Sakamaki Jun'ichi Honda Hajime Imai Ei'ichi Hatori Kuniyuki Shimada Katsuhiko Matsuno Koichiro |
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| Affiliation: | Department of BioEngineering, Nagaoka University of Technology, Nagaoka 940-2188, Japan. |
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| Abstract: | The sliding velocity of actin filaments was found to increase in the presence of ATP analogues. At 0.5 mM ATP, the presence of 2.0 mM of AMP-PNP enhanced the filament velocity from 3.2 up to 4.5 microm/s. However, 2 mM ADP decreased the velocity down to 1.1 microm/s. The results suggest that the complex conformations of myosin cross-bridges interacting with an actin filament in the presence of ATP analogues makes the entire filament move faster. |
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