Dexamethasone suppressibility of plasma pregnenolone or dehydroepiandrosterone in gonadectomized patients. |
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Authors: | S Nishida S Matsumura M Horino M Matsuki H Oyama A Tenku K Kakita H Tanaka Y Omukai |
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Institution: | Department of Medicine, Division of Endocrinology, Department of Urology, and Department of Endocrine Surgery, Kawasaki Medical School, Kurashiki, Okayama, 701-01 Japan |
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Abstract: | The 9 AM dexamethasone suppression test was carried out in gonadectomized patients, and plasma pregnenolone or dehydroepiandrosterone (DHA) was radioimmunoassayed following various amounts of dexamethasone administration. Pregnenolone, as well as the plasma ACTH level, was completely suppressed with 1 mg dexamethasone, whereas 4 mg or 8 mg of dexamethasone was needed to induce a complete DHA suppression. These findings suggest that the gonads alone contribute to the poor dexamethasone suppressibility of pregnenolone in normal subjects, and that adrenal DHA secretion might be also regulated by an unidentified factor other than ACTH, which would be suppressed with large doses of dexamethasone. |
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Keywords: | Pregnenolone 3β-hydroxy-5-pregnen-20-one Dehydroepiandrosterone 3β-hydroxy-5-androsten-17-one Dexanethasone 9-fluoro-11β 17 21-trihydroxy-16α-methy1-1 4-pregnadiene-3 20-dione |
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