A tryptic peptide from beta-casein depresses protein synthesis and degradation and enhances ureogenesis in primary cultures of rat hepatocytes |
| |
Authors: | A Takenaka Y Ohishi T Noguchi H Naito |
| |
Affiliation: | Department of Agricultural Chemistry, Faculty of Agriculture, University of Tokyo, Japan. |
| |
Abstract: | 1. A peptide which enhances ureogenesis in primary cultured hepatocytes of rats was isolated from a tryptic digest of bovine beta-casein. 2. The structure of the peptide was Ala-Val-Pro-Tyr-Pro-Gln-Arg which is located from 177th to 183rd residues from N-terminal of beta-casein. 3. The peptide also showed the activity to inhibit protein synthesis and protein degradation. 4. It also inhibited DNA synthesis of hepatocytes induced by insulin and/or epidermal growth factor. |
| |
Keywords: | |
|