1'-carbon hydroxylation of deoxyribose as the mechanism of cleavage of poly(dA) by manganese porphyrin combined with potassium monopersulfate |
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| Authors: | J Bernadou B Lauretta G Pratviel B Meunier |
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| Institution: | Laboratoire de Chimie de Coordination du C.N.R.S., Toulouse. |
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| Abstract: | Polyadenylic acid, poly(dA), was readily cleaved at neutral pH by meso-tetrakis (4-N-methylpyridyl) porphyrinatomangangeseIII pentaacetate after being activated by potassium monopersulfate. Spontaneously free adenine was released, and after heating an unstable sugar degradation product identified as 5-methylene-2-furanone was evidenced, indicating that C'1-H is the main target of the porphyrin high-valent metal-oxo species. |
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