A system to simulate gas exchange in humans to control quality of metabolic measurements |
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Authors: | F Prieur T Busso J Castells R Bonnefoy H Benoit A Geyssant and C Denis |
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Institution: | (1) Laboratoire de Physiologie-Groupement d'Interêt Public Exercice, Faculté de Médecine Saint-Etienne, 15 rue Ambroise Paré, F-42023 Saint-Etienne Cedex 2, France, FR;(2) Centre Hospitalier Universaire de Saint-Etienne, Pavillon 12 H?pital de St Jean Bonnefonds, F-42055 Saint-Etienne Cedex 2, France, FR |
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Abstract: | We have developed a gas exchange simulation system (GESS) to assess the quality control in measurements of metabolic gas
exchange. The GESS simulates human breathing from rest to maximal exercise. It approximates breath-by-breath waveforms, ventilatory
output, gas concentrations, temperature and humidity during inspiration and expiration. A programmable motion control driving
two syringes allows the ventilation to be set at any tidal volume (V
T), respiratory frequency (f), flow waveform and period of inspiration and expiration. The GESS was tested at various combinations of V
T (0.5–2.5 l) and f (10–60 stroke · min−1) and at various fractional concentrations of expired oxygen (0.1294–0.1795); and carbon dioxide (0.0210–0.0690) for a pre-set
flow waveform and for expired gases at the same temperature and humidity as room air. Expired gases were collected in a polyethylene
bag for measurement of volume and gas concentrations. Accuracy was assessed by calculating the absolute and relative errors
on parameters (error = measured−predicted). The overall error in the gas exchange values averaged less than 2% for oxygen
uptake and carbon dioxide output, which is within the accuracy of the Douglas bag method.
Accepted: 4 June 1998 |
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Keywords: | Human breathing simulation Oxygen uptake validity Metabolic measurement |
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