3-(4-Aminobutyn-1-yl)pyridines: binding at alpha 4 beta 2 nicotinic cholinergic receptors |
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| Authors: | Dogruer Deniz Lee Mase Dukat Malgorzata Damaj M Imad Martin Billy R Glennon Richard A |
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| Affiliation: | Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, VA 23298-0540, Richmond, USA. |
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| Abstract: | The binding of a series pyridylbutynylamines 6 was examined at alpha4beta2 nACh receptors. Structural modifications, comparing 6 with pyridyl ethers 2, did not consistently result in parallel effects on receptor affinity, suggesting possible differences in their modes of binding. Furthermore, the binding of amine 6a seemed to be accounted for by the newer vector pharmacophore models. |
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