A synthetic glycopeptide of human myelin oligodendrocyte glycoprotein to detect antibody responses in multiple sclerosis and other neurological diseases |
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| Authors: | Mazzucco S Matà S Vergelli M Fioresi R Nardi E Mazzanti B Chelli M Lolli F Ginanneschi M Pinto F Massacesi L Papini A M |
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| Affiliation: | Dipartimento di Chimica Organica Ugo Schiff, Università degli Studi di Firenze, Italy. |
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| Abstract: | Glycopeptides of hMOG(30-50) containing a glucosyl moiety on the side-chains of Asn, Ser or Hyp at position 31 were synthesised. Antibody titres to hMOG(30-50) and to its glucoderivatives were measured by ELISA in sera of patients affected by different neurological diseases. Anti-hMOG(30-50) antibodies were detected only using the glycopeptide [Asn31(N-Glc)]hMOG(30-50). |
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