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Involvement of protein HMG1 in DNA replication |
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| Authors: | E A Alexandrova L N Marekov B G Beltchev |
| Institution: | Institute of Molecular Biology, Bulgarian Academy of Sciences, Sofia 1113, Bulgaria |
| Abstract: | Antibodies against HMG1 inhibit the incorporation of 3H]thymidine in Ehrlich ascites cell nuclei. By the use of specific inhibitors it is shown that HMG1 is needed for the action of the replicative DNA polymerase and not for the reparative one. This is supported by the fact that the addition of exogenous HMG1 to the nuclei enhances the replication process. |
| Keywords: | High mobility group protein 1 Antibody DNA replication Ehrlich ascites cell nucleus HMG high mobility group NEM ddTTP 2' 3'-dideoxythymidine-5'-triphosphate |
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