Heterogeneity of hepatic microsomal UDP-glucuronosyltransferase(s) activities: comparison between human and mammalian species activities |
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Authors: | J A Boutin B Antoine A M Batt G Siest |
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Affiliation: | 1. Laboratoire de Biochimie Pharmacologique, No. 698, Faculte des Sciences Pharmaceutiques et Biologiques, 30 rue Lionnois 54000, Nancy France;2. Centre du Medicament ERA-CNRS, No. 698, Faculte des Sciences Pharmaceutiques et Biologiques, 30 rue Lionnois 54000, Nancy France |
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Abstract: | The first comparative profiles of UDP-glucuronosyltransferase(s) (UDPGT) activities obtained under standard conditions in vitro in mammals (man, rat [Wistar and Gunn], mouse, monkey [Papio papio and Cynomolgus], pig, guinea pig, rabbit, dog) are presented for 16 aglycones. A decreasing scale of these activities was obtained from planar to bulky molecules. The scale was identical for each of the mammals studied, including man. Statistical analysis of the results revealed a division of the aglycones into three groups, one being correlated with the molecular form called GT1 the two others with the GT2 form. The profile of activities in the Gunn rat revealed very weak activity towards planar molecules (GT1). These results provide evidence that under standard conditions, human UDPGT activities are comparable to those from other animals. |
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Keywords: | UDP-Glucuronosyltransferase(s) - Heterogeneity - Man - Guinea pig - Wistar rat - Gunn rat - Monkey HPPH, 5-(hydroxyphenyl)phenylhydantoin UDPGa, UDP-glucuronate (disodium salt) UDPGT, UDP-glucuronyltransferase |
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