The effects of lipoxygenase metabolites of arachidonic acid on human myometrial contractility |
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| Authors: | Phillip R. Bennett M.B. Murdoch G. Elder M.D. Leslie Myatt Ph.D. |
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| Affiliation: | 1. Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg, MB, Canada;2. Biology of Breathing Group, Children''s Hospital Research Institute of Manitoba, Winnipeg, MB, Canada;3. Department of Human Anatomy and Cell Science, University of Manitoba, Winnipeg, MB, Canada;4. Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MB, Canada;5. Department of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada;6. Manitoba Centre for Proteomics and Systems Biology, University of Manitoba, Winnipeg, MB, Canada;1. Doping Control Center, Korea Institute of Science and Technology, Hwarang-ro 14-gil 5, Seongbuk-gu, Seoul, 02792, Korea;2. Department of Chemistry, Sogang University, Seoul, 04107, Korea;3. Institute for Life & Environmental Technology, Smartive Corporation, Dobong-ro 110na-gil, Dobong-gu, Seoul, 01454, Korea;4. Department of Pharmaceutical Analysis, College of Pharmacy, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul, 06974, Korea |
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| Abstract: | The effects of the lipoxygenase products of arachidonic acid, 5- and 12-hydroxyeicosatetraenoic acid (5- and 12-HETE) and leukotriene B4 (LTB4), on the spontaneous contractility of lower uterine segment human myometrial strips obtained prior to labour have been studied . 5-HETE gave a dose- dependent (10–500ng) increase in both the rate of contractions and overall contractility of myometrial strips while 12-HETE and LTB4 had no effect at the same concentrations. Prostaglandin F2 (50ng) contracted all myometrial strips in a similar pattern to 5-HETE but was approximately 10 times more potent. The effect of 5-HETE may be direct or perhaps indirect via interaction with the cyclo-oxygenase pathway. The findings do not disprove the contention that the onset of parturition may be characterized by a switch in arachidonic acid metabolism in intra-uterine tissues from lipoxygenase to cyclo-oxygenase products. |
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