Liver cell specific targeting of peptide nucleic acid oligomers |
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| Authors: | Zhang X Simmons C G Corey D R |
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| Institution: | Department of Pharmacology and Biochemistry, University of Texas Southwestern Medical Center at Dallas, 75390-9041, USA. |
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| Abstract: | Chimeric molecules consisting of peptide nucleic acid (PNA) and lactose have been synthesized to test the hypothesis that lactose moieties can promote cell-specific uptake of PNAs. We find that lactose modified PNAs rapidly enter liver-derived HepG2 cells while unmodified PNAs do not and that lactose modified PNAs can inhibit cellular telomerase. |
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