Zinc supplementation does not inhibit basal and metoclopramide-stimulated prolactinemia secretion in healthy men. |
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| Authors: | Ana V B Castro Berenice B Mendon?a Walter Bloise Tadao Shuhama José Brand?o-Neto |
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| Institution: | Unidade de Endocrinologia e Metabologia, Faculdade de Medicina, UNESP, Botucatu-S?o Paulo, Brasil. |
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| Abstract: | Dopamine (DA) and zinc (Zn++) share common mechanisms in their inhibition of prolactin (PRL) secretion. Both substances are present in the same brain areas, where Zn++ is released together with DA, suggesting a modulatory effect of Zn++ on dopaminergic receptors. The aim of the present study was to evaluate the effect of Zn++ supplementation on basal and PRL secretion stimulated by metoclopramide (MCP), a dopaminergic antagonist. Seven healthy men were evaluated in controlled study, where MCP (5 mg) was given intravenously, before and after 3 months of oral Zn++ (25 mg) administration. Our results indicate that chronic Zn++ administration does not change basal or MCP-stimulated plasma PRL secretion suggesting that, in humans, Zn++ does not interfere on PRL secretion mediated through dopaminergic receptors. |
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