Homo and heterodimers of ddI, d4T and AZT: influence of (5'-5') thiolcabonate-carbamate linkage on anti-HIV activity |
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| Authors: | Taourirte M Lazrek H B Rochdi A Vasseur J J Engels J W |
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| Affiliation: | Faculty of Sciences and Techniques, Marrakech, Morocco. |
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| Abstract: | New homo and heterodimers of ddI, d4T and AZT with (5-5) thiolcarbonate-carbamate linkages have been prepared with the aim of testing them against wild type and NNRTI resistant HIV mutants. The prepared dimers showed a low activity in comparison to the parent drug. |
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