Effective DNA cleavage by bleomycin-vanadium(IV) complex plus hydrogen peroxide |
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| Authors: | J Kuwahara T Suzuki Y Sugiura |
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| Affiliation: | 1. Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden;2. Sachs’ Children''s Hospital, Stockholm, Sweden;1. The BioMEMS Research Group, School of Science, RMIT University, Australia;2. Ecotoxicology Research Group, School of Science, RMIT University, Australia;3. Centre for Environmental Sustainability and Remediation (EnSuRe), RMIT University, Melbourne, Australia;4. Centre for Additive Manufacturing, RMIT University, Melbourne, Australia;1. Microsystems Fabrication Laboratory, Department of Mechanical Engineering, Indian Institute of Technology, Kanpur, UP, 208016, India;2. Chemistry Department, Indian Institute of Technology, Kanpur, UP, 208016, India;3. Design Program, Indian Institute of Technology, Kanpur, UP, 208016, India;1. School of Materials Science and Engineering, University of Science and Technology of China, Hefei 230026, China;2. Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China;3. Shenyang National Laboratory for Materials Science, Shenyang 110016, China;4. Jiangsu Gunuo New Materials Technology Go., Ltd., Yancheng 224051, China |
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| Abstract: | It has been firstly found that the bleomycin-vanadyl(IV) complex is effectively capable of cleaving DNA in the presence of hydrogen peroxide. The 1:1 bleomycin-VO(IV) complex has been characterized by ESR and electronic absorption spectra, and its ESR parameters (go = 1.982 and Ao = 93.5 G) are indicative of VO(N5) coordination type for the metal-binding environment. The mode of nucleotide sequence cleavage induced by the present bleomycin-VO(IV)-H2O2 complex system was appreciably different from the corresponding Fe(III) complex system. Of special interest is the fact that the bleomycin-vanadium complex system more preferentially attacked G-A(5'----3') sequences than the bleomycin-iron complex system. |
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