| Two New Cytotoxic Sesquiterpenoids from Eupatorium lindleyanum DC. |
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| 作者姓名： | Jun Huo Sheng-Ping Yang Jian Ding Jian-Min Yue |
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| 作者单位： | State Key Laboratory of Drug Research, Institute of Materia Medica, Shanghai Institute for Biological Sciences, the Chinese Academy of Sciences, Shanghai 201203, China |
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| 基金项目： | 中国科学院资助项目;国家重点基础研究发展计划(973计划) |
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| 摘 要： |
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| 关 键 词： | 倍半萜类化合物 细胞毒素 泽兰属植物 光谱分析 |
| 收稿时间： | 2005-04-13 |
| 修稿时间： | 2005-04-132005-09-20 |
Two New Cytotoxic Sesquiterpenoids from Eupatorium lindleyanum DC. |
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| Authors: | Jun Huo Sheng-Ping Yang Jian Ding Jian-Min Yue |
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| Institution: | State Key Laboratory of Drug Research, Institute of Materia Medica, Shanghai Institute for Biological Sciences, the Chinese Academy of Sciences, Shanghai 201203, China |
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| Abstract: | Two new sesqulterpenold lactones, namely eupallnllides K and L, were isolated from Eupatorlum Ilndleyanum DC. Their structures were determined by spectral methods, Including 1 D-and 2D-NMR spectra. Cytotoxlc evaluatlon showed that eupallnlllde L exhibited potent cytotoxlclty against P-388 and A-549 tumor cell lines with IC50 values of 0.17 and 2.60 p, mol/L, respectively. |
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| Keywords: | eupalinilides K and L Eupatorium lindleyanum sesquiterpenoid |
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