Two new lathyrane-type diterpenoid glycosides with IL-6 production inhibitory activity from the roots of Euphorbia kansui |
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| Authors: | Young-Mi Kim Jongmin Ahn Hee-Sung Chae Young Hee Choi Jinwoong Kim Young-Won Chin |
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| Affiliation: | 1. College of Pharmacy and Integrated Research Institute for Drug Development, Dongguk University-Seoul, Gyeonggi-do 10326, Republic of Korea;2. College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea |
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| Abstract: | As part of our ongoing search for anti-inflammatory compounds from higher plants, we isolated and elucidated two new diterpenoid glycosides, kansuingol A (1) and kansuingol B (2), from the roots of Euphorbia kansui. These structures were elucidated by extensive spectroscopic methods such as NMR and MS. Compounds were assessed for their IL-6 production inhibitory activity in PMA?+?A23187-stimulated HMC-1 cells. As a result, compounds 1 and 2 exerted inhibitory activities in the production of IL-6 with IC50 values of 2.96, and 1.94?μM, respectively. Further, kansuingol A (1) decreased mRNA expressions of TNF-α and IL-6. |
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| Keywords: | Kansuingol A Kansuingol B Anti-inflammatory IL-6 TNF-α Diterpenoid |
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