Chemical constituents from Taraxacum officinale and their α-glucosidase inhibitory activities |
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Authors: | Janggyoo Choi Kee Dong Yoon Jinwoong Kim |
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Institution: | 1. College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Seoul 08826, Republic of Korea;2. College of Pharmacy, The Catholic University of Korea, Bucheon 14662, Republic of Korea |
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Abstract: | Three novel butyrolactones (1–3) and butanoates (4–6), namely taraxiroside A–F, were isolated from Taraxacum officinale along with twenty-two known compounds (7–28). Their chemical structures were elucidated by interpretation of spectroscopic data and comparison with those of literatures. All isolates were evaluated for their α-glucosidase inhibitory activities. Novel compounds 1–6 (IC50 145.3–181.3?μM) showed inhibitory activities similar to that of acarbose (IC50 179.9?μM). Compound 7 and 12 were the most potent inhibitor with IC50 values of 61.2 and 39.8?μM respectively. Compounds 2 and 12 showed as mixed-type inhibition, whereas compound 7 and acarbose showed competitive inhibition. |
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Keywords: | Butyrolactone Butanoate α-Glucosidase inhibitor Mixed-type inhibition |
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