New butenolide derivatives from the marine sponge-derived fungus Aspergillus terreus |
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Authors: | Yating Sun Jingtang Liu Lei Li Chi Gong Shuping Wang Fan Yang Huiming Hua Houwen Lin |
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Institution: | 1. Research Center for Marine Drugs, State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacy, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China;2. Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning, China |
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Abstract: | Two new butenolide derivatives (±)-asperteretal D ((±)-1) and asperteretal E (2) containing rare 2-benzyl-3-phenyl substituted lactone core, together with nine known analogues (3–11) were obtained from a fungus Aspergillus terreus derived from the marine sponge Phakellia fusca. All the structures were elucidated on the basis of extensive NMR spectroscopic data. The chiral chromatography analyses allowed the separation of the (±)-asperteretal D, of which the absolute configurations were determined by comparing the experimental to calculated electronic circular dichroic (ECD) spectra. Compounds (±)-1, 2–5, and 7 exhibited potent inhibitory activities against α-glucosidase with IC50 values ranging from 8.65 to 20.3?µM (positive control acarbose with an IC50 value of 320?µM). In addition, derivatives 5–8 also showed moderate antioxidant activities. |
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Keywords: | Butenolide derivatives Antioxidant activity |
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