Design,synthesis and biological evaluation of glutamic acid derivatives as anti-oxidant and anti-inflammatory agents |
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| Authors: | Suvarna H Pagire Eunhye Lee Haushabhau S Pagire Eun Jung Bae Soo Jung Ryu Dahye Lee Min Hee Kim Geum Ran Kim Kyu-Seok Hwang Sukyung Ahn Jin Hee Maeng Jin Sook Song Myung Ae Bae Don Hang Lee Jin Hee Ahn |
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| Institution: | 1. Department of Chemistry, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea;2. Utah-Inha Drug Delivery Systems (DDS) and Advanced Therapeutics Research Center, Incheon 21988, Republic of Korea;3. Drug Discovery Division, Korea Research Institute of Chemical Technology, Daejeon 305-600, Republic of Korea |
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| Abstract: | A series of glutamic acid derivatives was synthesized and evaluated for their antioxidant activity and stability. We found several potent and stable glutamic acid derivatives. Among them, compound 12b exhibited good in vitro activity, chemical stability and cytotoxicity. A prototype compound 12b showed an anti-inflammatory effect in LPS-stimulated RAW 264.7 cell lines and in a zebrafish model. |
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| Keywords: | Glutamic acid derivatives Ramalin Antioxidant |
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