Selective incorporation of foreign functionality into fibrin gels through a chemically modified DNA aptamer |
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| Authors: | Hiroto Fujita Yusuke Inoue Masayasu Kuwahara |
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| Institution: | Graduate School of Science and Technology, Gunma University, 1-5-1 Tenjin-cho, Kiryu, Gunma 376-8515, Japan |
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| Abstract: | We found for the first time that a thrombin-binding DNA aptamer (TBA) is selectively entrapped in fibrin gels during the gel growth reaction catalyzed by thrombin. Furthermore, using this phenomenon, we successfully demonstrated multiple incorporation of amphiphilic aliphatic groups into fibrin gels via chemically modified TBA. |
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| Keywords: | Fibrin Fibrinogen Modified DNA aptamer Thrombin Selective entrapment |
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