Docetaxel prodrug self-assembled nanosystem: Synthesis,formulation and cytotoxicity |
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Authors: | Fanbo Jing Qie Guo Wen Xu Haijun Qu Zhongguo Sui |
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Affiliation: | Department of Pharmacy, Affiliated Hospital of Qingdao University, Qingdao, China |
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Abstract: | Conventional drug delivery systems of docetaxel (DTX) are challenged with low drug loading efficiency and potential carriers-induced toxicity. In this work, a docetaxel prodrug self-assembled nanosystem was designed and synthesized by conjugating docetaxel with oleic acid (OA) exploring a thioether as the linker, which is redox-sensitive to the redox environment within tumor cells. Notably, the carrier-free nanomedicine which does not need any carrier has obviously high drug loading that reaches 58%. Moreover, the cytotoxicity of DTX-S-OA maintains an equal level with DTX. The novel prodrug conjugate therefore has a promising perspective as carrier-free nanomedicine for cancer therapy due to its high drug loading property, redox-sensitive release and long circulation mechanism. |
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Keywords: | Docetaxel Oleic acid Thioether bond Self-assembled nanosystem Redox-sensitive |
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