Bacicyclin,a new antibacterial cyclic hexapeptide from Bacillus sp. strain BC028 isolated from Mytilus edulis |
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| Authors: | Jutta Wiese Usama Ramadan Abdelmohsen Asa Motiei Ute Hentschel Humeida Johannes F Imhoff |
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| Institution: | 1. GEOMAR Helmholtz Centre for Ocean Research Kiel, RD3 Marine Microbiology, Düsternbrooker Weg 20, 24105 Kiel, Germany;2. Department of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia 61519, Egypt;3. Christian-Albrechts University of Kiel, 24118 Kiel, Germany;4. Stockholm University, Department of Environmental Science and Analytical Chemistry, (ACES), 10691 Stockholm, Sweden |
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| Abstract: | A new cyclic hexapeptide, cyclo-(Gly-Leu-Val-IIe-Ala-Phe), named bacicyclin (1), was isolated from a marine Bacillus sp. strain associated with Mytilus edulis. The sequences of the amino acid building blocks of the cyclic peptide and its structure were determined by 1D- and 2D-NMR techniques. Marfey’s analysis showed that the amino acid building blocks had L-configuration in all cases except for alanine and phenylalanine, which had D-configuration. Bacicyclin (1) exhibited antibacterial activity against the clinically relevant strains Enterococcus faecalis and Staphylococcus aureus with minimal inhibitory concentration values of 8 and 12?µM, respectively. These results demonstrate the potential of marine bacteria as a promising source for the discovery of new antibiotics. |
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| Keywords: | Cyclic peptide Marfey’s analysis Antibacterial activity |
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