Two new coumarins and a new xanthone from the leaves of Rhizophora mucronata |
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| Authors: | Kaori Taniguchi Mariko Funasaki Akio Kishida Samir K Sadhu Firoj Ahmed Masami Ishibashi Ayumi Ohsaki |
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| Institution: | 1. Institute of Biomaterials and Bioengineering, Tokyo Medicinal and Dental University, Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan;2. College of Humanities and Sciences, Nihon University, Setagaya-ku, Tokyo 156-8550, Japan;3. Pharmacy Discipline, Khulna University, Khulna 9208, Bangladesh;4. Department of Pharmaceutical Chemistry, University of Dhaka, Dhaka 1000, Bangladesh;5. Graduate School of Pharmaceutical Sciences, Chiba University, Chuo-ku, Chiba 260-8675, Japan |
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| Abstract: | Two new coumarins (1, 2) and a new xanthone (3), together with 14 known compounds—eight coumarins (4, 5, 9, 10, 12–15), three xanthones (11, 16, 17), a benzoic acid (6) and two flavonones (7, 8)—were isolated from the leaves of Rhizophora mucronata. The structures of the compounds were elucidated by spectroscopic (IR, MS, and NMR) analyses. The isolated compounds were tested for cytotoxicity against human cancer cell lines HL-60 and HeLa. Among these compounds, only compound 16 inhibited the growth of both HeLa (IC50?=?4.8?μM) and HL-60 (IC50?=?1.0?μM) cells. Compounds 4, 7, 10, and 12 exhibited moderate activity against HeLa cells (IC50?=?3.8–8.3?μM). Compounds 5, 9, 11, and 17 showed moderate activity against HL-60 cells (IC50?=?2.2–6.3?μM). Higher selectivity against HL-60 cell lines was observed for compounds 5, 9, 11, and 16 with SI values (NIH 3T3/HL-60) of 8.6, 19.2, 9.4, and 10.2, respectively. |
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| Keywords: | Coumarin Xanthone Cytotoxicity HL-60 HeLa |
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